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Testing >> Contaminants >> Melamine


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Melamine is a widely-used intermediate, mainly employed as a raw material for producing melamine resin and is a chemical most often found in plastic materials. Long-term or mass intake of melamine has toxic effects and may lead to reproductive damage or bladder or kidney stones, which can also lead to bladder cancer.

Melamine was initially found in food stuffs exported to the USA in early 2007 contained in contaminated wheat gluten and rice protein and had resulted in the death of several pet dogs and cats. Thereafter, this contamination was found in many other products that use protein content as an important quality indicator.

More recently melamine has been found to be contaminating human foods, in particular milk powder, milk and yoghurt and was reported to have been used in 22 brands of infant formula. More than 53,000 infants have been diagnosed with severe traumas such as urinary tract complications and acute kidney failure. Several infant deaths have also been linked to the contamination.

The addition of melamine to raw milk, in order to imitate an enhanced protein value when the protein content is determined, was defined as the primary cause of this scandal. Latest investigations indicate that melamine contamination is widely spread throughout the Chinese dairy industry and officials have estimated that about 20 % of the dairy companies tested in China have sold products tainted with melamine.

Melamine testing is now one of the "must-do's" when exporting feed materials to the USA and EU. The FDA has increased powers of detention without inspection of imports of vegetable proteins from China. The European Commission has asked Member States to control consignments of wheat gluten, corn gluten, corn meal, soy protein, rice bran, and rice protein concentrate originating from third party countries. As well as melamine, testing is done for other structurally related compounds such as cyanuric acid, ammelide and ammeline.

Eurofins Analytical Offer

Eurofins offers two different methods for the analysis of melamine in feed, plant protein products, dairy products and food containing milk products.

Using GC-MS (according to the official FDA method: MelamineAnalogs.htm0) melamine and its homologues cyanuric acid, ammeline and ammelide can be detected in the ppm range. Limit of Detection (LOD) for melamine: 2 mg/kg (ppm).

A very sensitive LC-MS/MS method is offered for the analysis infant food and dairy products. Using this method melamine can be detected in the ppb range. (Limit of Quantification (LOQ): < 0.1 mg/kg). New method was developed by Eurofins China currently, the LOQ: 10 ug/kg.

The following compounds are among those covered by the current FDA GC-MS method:

  • Melamine (CAS 108-78-1)
  • Ammeline (CAS 645-92-1)
  • Cyanuric Acid (CAS 108-80-5)
  • Ammelide (CAS 645-93-2)

Our laboratories constantly invest in R&D to develop and validate new analytical methods. We also keep a close eye, on a daily basis, on scientific developments and changes to national and international legislation. Please do not hesitate to contact our branch office.